ELASPIC home << Job #oncokb << P00533.G719A
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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P00533.G719A

Detailed results for job #oncokb produced by ELASPIC
P00533, Epidermal growth factor receptor:
G719A
1
1210
Recep_L_d..
Recep_..
Furin..
Pkinase_Tyr
E7ETZ0, Calmodulin:
1
150
EF-hand_7
EF-hand_7
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Model: Wild-type | Mutant | Both
Protein: P00533 | E7ETZ0 | Cofactors | All
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P00533.G719A

Completed successfully

Protein, domain: P00533 Pkinase_Tyr

Interacting with: E7ETZ0 EF-hand_7

PDB templates used: 2x0g_A, 2x0g_B

Seq identity: 0.282, 0.985 Model score: 1.871

ELASPIC ΔΔG: 0.721

ELASPIC2 (EL2) score: 1.730

Mutation in databases: UniProt, COSMIC.

Download:  PDBwt   | PDBmut

Citation

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