ELASPIC home << Job #oncokb << P00533.E709A
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

P00533.E709A

Detailed results for job #oncokb produced by ELASPIC
P00533, Epidermal growth factor receptor:
E709A
1
1210
Recep_L_d..
Recep_..
Furin..
Pkinase_Tyr
HCK isoform 4, Isoform 4 of Tyrosine-protein kinase HCK:
1
525
SH3_1
SH2
Pkinase_Tyr
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P00533.E709A

Completed successfully

Protein, domain: P00533 Pkinase_Tyr

Interacting with: HCK isoform 4 Pkinase_Tyr

PDB templates used: 3ika_A, 3ika_B

Seq identity: 0.949, 0.365 Model score: -0.051

ELASPIC ΔΔG: 2.056

ELASPIC2 (EL2) score: 1.188

Mutation in databases: UniProt, COSMIC.

Download:  PDBwt   | PDBmut

Citation

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