ELASPIC home << Job #oncokb << P00533.E709A
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

P00533.E709A

Detailed results for job #oncokb produced by ELASPIC
P00533, Epidermal growth factor receptor:
E709A
1
1210
Recep_L_d..
Recep_..
Furin..
Pkinase_Tyr
KPCB isoform 2, Isoform Beta-II of Protein kinase C beta type:
1
673
C1_1
C1_1
C2
Pkinase+Pkinase_C
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P00533.E709A

Completed successfully

Protein, domain: P00533 Pkinase_Tyr

Interacting with: KPCB isoform 2 Pkinase+Pkinase_C

PDB templates used: 4i24_B, 4i24_A

Seq identity: 0.962, 0.264 Model score: 0.377

ELASPIC ΔΔG: 2.024

ELASPIC2 (EL2) score: 1.227

Mutation in databases: UniProt, COSMIC.

Download:  PDBwt   | PDBmut

Citation

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