ELASPIC home << Job #oncokb << P00533.D761N
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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P00533.D761N

Detailed results for job #oncokb produced by ELASPIC
P00533, Epidermal growth factor receptor:
D761N
1
1210
Recep_L_d..
Recep_..
Furin..
Pkinase_Tyr
J3QLU9, Receptor tyrosine-protein kinase erbB-2:
1
1055
Recep_L_do..
Pkinase_Tyr
Furin-like
GF_recep..
Recep_L_do..
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Protein: P00533 | J3QLU9 | Cofactors | All
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P00533.D761N

Completed successfully

Protein, domain: P00533 Pkinase_Tyr

Interacting with: J3QLU9 Pkinase_Tyr

PDB templates used: 3ika_A, 3ika_B

Seq identity: 0.949, 0.784 Model score: -0.616

ELASPIC ΔΔG: 0.382

ELASPIC2 (EL2) score: -0.635

Mutation in database: COSMIC.

Download:  PDBwt   | PDBmut

Citation

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