ELASPIC home << Job #oncokb << P00519.Y253H
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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P00519.Y253H

Detailed results for job #oncokb produced by ELASPIC
P00519, Tyrosine-protein kinase ABL1:
Y253H
1
1130
F_act..
SH..
SH2
Pkinase_Tyr
ACAP1, Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1:
1
740
PH
ArfGap+Ank
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Model: Wild-type | Mutant | Both
Protein: P00519 | ACAP1 | Cofactors | All
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P00519.Y253H

Completed successfully

Protein, domain: P00519 Pkinase_Tyr

Interacting with: ACAP1 ArfGap+Ank

PDB templates used: 3zu7_A, 3zu7_B

Seq identity: 0.257, 0.377 Model score: 2.247

ELASPIC ΔΔG: 0.609

ELASPIC2 (EL2) score: 0.992

Mutation in databases: ClinVar, COSMIC.

Download:  PDBwt   | PDBmut

Citation

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