ELASPIC home << Job #oncokb << P00519.T315I
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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P00519.T315I

Detailed results for job #oncokb produced by ELASPIC
P00519, Tyrosine-protein kinase ABL1:
T315I
1
1130
F_act..
SH..
SH2
Pkinase_Tyr
SHANK3, SH3 and multiple ankyrin repeat domains protein 3:
1
1731
S..
PDZ
..
Ank_2
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Protein: P00519 | SHANK3 | Cofactors | All
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P00519.T315I

Completed successfully

Protein, domain: P00519 Pkinase_Tyr

Interacting with: SHANK3 Ank_2

PDB templates used: 3zu7_A, 3zu7_B

Seq identity: 0.257, 0.301 Model score: 1.096

ELASPIC ΔΔG: 0.973

ELASPIC2 (EL2) score: 2.331

Mutation in database: COSMIC.

Download:  PDBwt   | PDBmut

Citation

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