ELASPIC home << Job #oncokb << P00519.H396P
x
Choose which mutations you want to be shown in the result table below.
Reset to show everything.
x
Status of calculations
: Completed with success
: Mutation not in domain
: Running
: In task queue
: Error
When calculations are done, you can click on each mutation to see their detailed results.
x
Try again
can be rerun by clicking the button:
RERUN
For more information about the error, contact us.
x
ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
For more information see the ELASPIC publication.
x
ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

P00519.H396P

Detailed results for job #oncokb produced by ELASPIC
P00519, Tyrosine-protein kinase ABL1:
H396P
1
1130
F_act..
SH..
SH2
Pkinase_Tyr
ASAP1, Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1:
1
1129
PH
SH..
ArfGap+Ank_2
Select affected interaction:

Switch to the slower HTML5 mode if the applet isn't showing.
Set mode: JAVA | HTML5
Set quality: Best | Normal | Worst
Model: Wild-type | Mutant | Both
Protein: P00519 | ASAP1 | Cofactors | All
Center camera: Protein | Mutation
Clone in larger window
Cartoon: On | Off | Translucent
Sticks: On | Off | Within Å:
Labels: On | Off | Only sticks

P00519.H396P

Completed successfully

Protein, domain: P00519 Pkinase_Tyr

Interacting with: ASAP1 ArfGap+Ank_2

PDB templates used: 3zu7_A, 3zu7_B

Seq identity: 0.257, 0.323 Model score: 1.589

ELASPIC ΔΔG: 1.288

ELASPIC2 (EL2) score: 1.211

Mutation in database: COSMIC.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.