ELASPIC home << Job #oncokb << P00519.F311L
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

P00519.F311L

Detailed results for job #oncokb produced by ELASPIC
P00519, Tyrosine-protein kinase ABL1:
F311L
1
1130
F_act..
SH..
SH2
Pkinase_Tyr
WNK2 isoform 3, Isoform 3 of Serine/threonine-protein kinase WNK2:
1
779
Pkinase
OSR1_C
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P00519.F311L

Completed successfully

Protein, domain: P00519 Pkinase_Tyr

Interacting with: WNK2 isoform 3 Pkinase

PDB templates used: 3fpq_B, 3fpq_A

Seq identity: 0.276, 0.896 Model score: 0.071

ELASPIC ΔΔG: 0.475

ELASPIC2 (EL2) score: 0.740

Mutation in database: COSMIC.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.