ELASPIC home << Job #oncokb << P00519.E281K
x
Choose which mutations you want to be shown in the result table below.
Reset to show everything.
x
Status of calculations
: Completed with success
: Mutation not in domain
: Running
: In task queue
: Error
When calculations are done, you can click on each mutation to see their detailed results.
x
Try again
can be rerun by clicking the button:
RERUN
For more information about the error, contact us.
x
ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
For more information see the ELASPIC publication.
x
ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

P00519.E281K

Detailed results for job #oncokb produced by ELASPIC
P00519, Tyrosine-protein kinase ABL1:
E281K
1
1130
F_act..
SH..
SH2
Pkinase_Tyr
GRB10, Growth factor receptor-bound protein 10:
1
594
BPS
RA+PH
SH2
Select affected interaction:

Switch to the slower HTML5 mode if the applet isn't showing.
Set mode: JAVA | HTML5
Set quality: Best | Normal | Worst
Model: Wild-type | Mutant | Both
Protein: P00519 | GRB10 | Cofactors | All
Center camera: Protein | Mutation
Clone in larger window
Cartoon: On | Off | Translucent
Sticks: On | Off | Within Å:
Labels: On | Off | Only sticks

P00519.E281K

Completed successfully

Protein, domain: P00519 Pkinase_Tyr

Interacting with: GRB10 BPS

PDB templates used: 2auh_A, 2auh_B

Seq identity: 0.409, 0.784 Model score: -0.332

ELASPIC ΔΔG: 0.643

ELASPIC2 (EL2) score: 0.908

Mutation run by user.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.