ELASPIC home << Job #oncokb << P00519.E281K
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

P00519.E281K

Detailed results for job #oncokb produced by ELASPIC
P00519, Tyrosine-protein kinase ABL1:
E281K
1
1130
F_act..
SH..
SH2
Pkinase_Tyr
GRB10 isoform 3, Isoform 2 of Growth factor receptor-bound protein 10:
1
536
BPS
RA+PH
SH2
Select affected interaction:

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P00519.E281K

Completed successfully

Protein, domain: P00519 Pkinase_Tyr

Interacting with: GRB10 isoform 3 BPS

PDB templates used: 2auh_A, 2auh_B

Seq identity: 0.409, 0.784 Model score: -0.332

ELASPIC ΔΔG: 0.643

ELASPIC2 (EL2) score: 0.908

Mutation run by user.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.