ELASPIC home << Job #oncokb << P00519.E281K
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
For more information see the ELASPIC publication.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

P00519.E281K

Detailed results for job #oncokb produced by ELASPIC
P00519, Tyrosine-protein kinase ABL1:
E281K
1
1130
F_act..
SH..
SH2
Pkinase_Tyr
ANKRA2, Ankyrin repeat family A protein 2:
1
313
Ank
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Protein: P00519 | ANKRA2 | Cofactors | All
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P00519.E281K

Completed successfully

Protein, domain: P00519 Pkinase_Tyr

Interacting with: ANKRA2 Ank

PDB templates used: 3zu7_A, 3zu7_B

Seq identity: 0.257, 0.346 Model score: 0.734

ELASPIC ΔΔG: 1.091

ELASPIC2 (EL2) score: 0.559

Mutation run by user.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.