ELASPIC home << Job #oncokb << P00519.E281K
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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P00519.E281K

Detailed results for job #oncokb produced by ELASPIC
P00519, Tyrosine-protein kinase ABL1:
E281K
1
1130
F_act..
SH..
SH2
Pkinase_Tyr
LRRK1, Leucine-rich repeat serine/threonine-protein kinase 1:
1
2015
An..
LRR
Miro
Pkinase
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Protein: P00519 | LRRK1 | Cofactors | All
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P00519.E281K

Completed successfully

Protein, domain: P00519 Pkinase_Tyr

Interacting with: LRRK1 Pkinase

PDB templates used: 3ik3_B, 3ik3_A

Seq identity: 0.993, 0.305 Model score: 0.342

ELASPIC ΔΔG: 0.275

ELASPIC2 (EL2) score: 0.750

Mutation run by user.

Download:  PDBwt   | PDBmut

Citation

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