ELASPIC home << Job #oncokb << P00519.E279K
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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P00519.E279K

Detailed results for job #oncokb produced by ELASPIC
P00519, Tyrosine-protein kinase ABL1:
E279K
1
1130
F_actin_b..
SH3_1
SH2
Pkinase_Tyr

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P00519.E279K

Completed successfully

Protein, domain: P00519 Pkinase_Tyr

Type: Core (stability)

PDB template used: 2g1t_B

Seq identity: 1.000 Model score: -1.401

ELASPIC ΔΔG: 0.575

ELASPIC2 (EL2) score: -1.921

Mutation in database: COSMIC.

Download:  PDBwt   | PDBmut

Citation

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