ELASPIC home << Job #oncokb << O96017.S428F
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
For more information see the ELASPIC publication.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

O96017.S428F

Detailed results for job #oncokb produced by ELASPIC
O96017, Serine/threonine-protein kinase Chk2:
S428F
1
543
FHA
Pkinase
CHK2 isoform 8, Isoform 8 of Serine/threonine-protein kinase Chk2:
1
289
FHA
Pkinase
Select affected interaction:

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O96017.S428F

Completed successfully

Protein, domain: O96017 Pkinase

Interacting with: CHK2 isoform 8 Pkinase

PDB templates used: 3i6u_A, 3i6u_B

Seq identity: 0.918, 0.875 Model score: -0.251

ELASPIC ΔΔG: 1.408

ELASPIC2 (EL2) score: 1.380

Mutation in database: UniProt.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.