ELASPIC home << Job #oncokb << O96017.I157T
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

O96017.I157T

Detailed results for job #oncokb produced by ELASPIC
O96017, Serine/threonine-protein kinase Chk2:
I157T
1
543
FHA
Pkinase
PLK1, Serine/threonine-protein kinase PLK1:
1
603
Pkinase
POLO_box
POLO_box
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Model: Wild-type | Mutant | Both
Protein: O96017 | PLK1 | Cofactors | All
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O96017.I157T

Completed successfully

Protein, domain: O96017 FHA

Interacting with: PLK1 Pkinase

PDB templates used: 3i6u_B, 3i6u_A

Seq identity: 1.000, 0.332 Model score: -0.162

ELASPIC ΔΔG: 0.346

ELASPIC2 (EL2) score: 0.454

Mutation in databases: UniProt, COSMIC.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.