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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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O75874.H133Q

Detailed results for job #oncokb produced by ELASPIC

O75874, Isocitrate dehydrogenase [NADP] cytoplasmic:
H133Q
1
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O75874.H133Q

Completed successfully

Protein, domain: O75874 Iso_dh

Type: Core (stability)

PDB template used: 1t09_A

Seq identity: 1.000 Model score: -0.647

ELASPIC ΔΔG: -2.231

ELASPIC2 (EL2) score: 1.487

Mutation in database: COSMIC.

Download:  PDBwt   | PDBmut

Citation


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