ELASPIC home << Job #oncokb << O60674.V617F
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
For more information see the ELASPIC publication.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

O60674.V617F

Detailed results for job #oncokb produced by ELASPIC
O60674, Tyrosine-protein kinase JAK2:
V617F
1
1132
Pkinase_Tyr
Pkinase_Tyr
FAK1 isoform 5, Isoform 5 of Focal adhesion kinase 1:
1
1065
Focal_AT
FERM_M
Pkinase_Tyr
Select affected interaction:

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O60674.V617F

Completed successfully

Protein, domain: O60674 Pkinase_Tyr

Interacting with: FAK1 isoform 5 Pkinase_Tyr

PDB templates used: 4l00_B, 4l00_A

Seq identity: 0.524, 0.286 Model score: -0.005

ELASPIC ΔΔG: 1.141

ELASPIC2 (EL2) score: -0.701

Mutation in databases: UniProt, COSMIC.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.