ELASPIC home << Job #oncokb << O60674.V617F
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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O60674.V617F

Detailed results for job #oncokb produced by ELASPIC
O60674, Tyrosine-protein kinase JAK2:
V617F
1
1132
Pkinase_Tyr
Pkinase_Tyr
ALK, ALK tyrosine kinase receptor:
1
1620
Pkinase_Tyr
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Protein: O60674 | ALK | Cofactors | All
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O60674.V617F

Completed successfully

Protein, domain: O60674 Pkinase_Tyr

Interacting with: ALK Pkinase_Tyr

PDB templates used: 4l00_B, 4l00_A

Seq identity: 0.524, 0.258 Model score: -0.353

ELASPIC ΔΔG: 1.290

ELASPIC2 (EL2) score: -0.801

Mutation in databases: UniProt, COSMIC.

Download:  PDBwt   | PDBmut

Citation

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