ELASPIC home << Job #oncokb << O60674.V1075F
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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O60674.V1075F

Detailed results for job #oncokb produced by ELASPIC
O60674, Tyrosine-protein kinase JAK2:
V1075F
1
1132
Pkinase_Tyr
Pkinase_Tyr
SOCS7, Suppressor of cytokine signaling 7:
1
581
SH2
SOC..
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Model: Wild-type | Mutant | Both
Protein: O60674 | SOCS7 | Cofactors | All
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O60674.V1075F

Completed successfully

Protein, domain: O60674 Pkinase_Tyr

Interacting with: SOCS7 SH2

PDB templates used: 4gl9_A, 4gl9_E

Seq identity: 0.951, 0.370 Model score: -0.662

ELASPIC ΔΔG: 0.635

ELASPIC2 (EL2) score: -0.334

Mutation run by user.

Download:  PDBwt   | PDBmut

Citation

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