ELASPIC home << Job #oncokb << O60674.L983F
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

O60674.L983F

Detailed results for job #oncokb produced by ELASPIC
O60674, Tyrosine-protein kinase JAK2:
L983F
1
1132
Pkinase_Tyr
Pkinase_Tyr
CDKN1B, Cyclin-dependent kinase inhibitor 1B:
1
198
CDI
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Model: Wild-type | Mutant | Both
Protein: O60674 | CDKN1B | Cofactors | All
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O60674.L983F

Completed successfully

Protein, domain: O60674 Pkinase_Tyr

Interacting with: CDKN1B CDI

PDB templates used: 1jsu_A, 1jsu_C

Seq identity: 0.330, 1.000 Model score: 0.331

ELASPIC ΔΔG: -0.108

ELASPIC2 (EL2) score: -0.338

Mutation run by user.

Download:  PDBwt   | PDBmut

Citation

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