ELASPIC home << Job #oncokb << O60674.I1018F
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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O60674.I1018F

Detailed results for job #oncokb produced by ELASPIC
O60674, Tyrosine-protein kinase JAK2:
I1018F
1
1132
Pkinase_Tyr
Pkinase_Tyr
FGFR1, Fibroblast growth factor receptor 1:
1
822
Pkinase_Tyr
I-set
I-set
I-set
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Model: Wild-type | Mutant | Both
Protein: O60674 | FGFR1 | Cofactors | All
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O60674.I1018F

Completed successfully

Protein, domain: O60674 Pkinase_Tyr

Interacting with: FGFR1 Pkinase_Tyr

PDB templates used: 3kxx_C, 3kxx_B

Seq identity: 0.380, 0.990 Model score: -0.463

ELASPIC ΔΔG: -0.369

ELASPIC2 (EL2) score: 0.742

Mutation run by user.

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Citation

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