ELASPIC home << Job #oncokb << O00459.G373R
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

O00459.G373R

Detailed results for job #oncokb produced by ELASPIC
O00459, Phosphatidylinositol 3-kinase regulatory subunit beta:
G373R
1
728
RhoGAP
SH2
SH2
LYN isoform 2, Isoform 2 of Tyrosine-protein kinase Lyn:
1
491
SH3_1
SH2
Pkinase_Tyr
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O00459.G373R

Completed successfully

Protein, domain: O00459 SH2

Interacting with: LYN isoform 2 SH2

PDB templates used: 2dx0_A, 2dx0_B

Seq identity: 0.370, 0.343 Model score: -0.259

ELASPIC ΔΔG: 0.666

ELASPIC2 (EL2) score: 1.926

Mutation in databases: UniProt, COSMIC.

Download:  PDBwt   | PDBmut

Citation

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