ELASPIC home << Job #oncokb << Q9UM73.F1174S
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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Q9UM73.F1174S

Detailed results for job #oncokb produced by ELASPIC
Q9UM73, ALK tyrosine kinase receptor:
F1174S
1
1620
Pkinase_Tyr
MP2K7 isoform 3, Isoform 3 of Dual specificity mitogen-activated protein kinase kinase 7:
1
435
Pkinase
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Q9UM73.F1174S

Completed successfully

Protein, domain: Q9UM73 Pkinase_Tyr

Interacting with: MP2K7 isoform 3 Pkinase

PDB templates used: 3qqu_C, 3qqu_B

Seq identity: 0.466, 0.236 Model score: 0.440

ELASPIC ΔΔG: 4.112

ELASPIC2 (EL2) score: 2.193

Mutation in database: COSMIC.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.