ELASPIC home << Job #oncokb << Q9UM73.C1156Y
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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Q9UM73.C1156Y

Detailed results for job #oncokb produced by ELASPIC
Q9UM73, ALK tyrosine kinase receptor:
C1156Y
1
1620
Pkinase_Tyr
MP2K7 isoform 4, Isoform 4 of Dual specificity mitogen-activated protein kinase kinase 7:
1
426
Pkinase
Select affected interaction:

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Q9UM73.C1156Y

Completed successfully

Protein, domain: Q9UM73 Pkinase_Tyr

Interacting with: MP2K7 isoform 4 Pkinase

PDB templates used: 3qqu_B, 3qqu_C

Seq identity: 0.457, 0.231 Model score: 0.424

ELASPIC ΔΔG: 4.194

ELASPIC2 (EL2) score: -0.976

Mutation in database: COSMIC.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.