ELASPIC home << Job #oncokb << Q15796.K420A
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
For more information see the ELASPIC publication.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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Q15796.K420A

Detailed results for job #oncokb produced by ELASPIC
Q15796, Mothers against decapentaplegic homolog 2:
K420A
1
467
MH1
MH2
SMAD3 isoform 3, Isoform 3 of Mothers against decapentaplegic homolog 3:
1
320
MH1
MH2
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Q15796.K420A

Completed successfully

Protein, domain: Q15796 MH2

Interacting with: SMAD3 isoform 3 MH2

PDB templates used: 1u7f_A, 1u7f_C

Seq identity: 0.970, 1.000 Model score: -0.912

ELASPIC ΔΔG: 3.261

ELASPIC2 (EL2) score: 2.503

Mutation run by user.

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Citation

If you use these results, please cite the papers on this page.