ELASPIC home << Job #oncokb << Q15382.Y35H
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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Q15382.Y35H

Detailed results for job #oncokb produced by ELASPIC
Q15382, GTP-binding protein Rheb:
Y35H
1
184
Ras
TSC2 isoform 3, Isoform 3 of Tuberin:
1
1763
Rap_GAP
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Q15382.Y35H

Completed successfully

Protein, domain: Q15382 Ras

Interacting with: TSC2 isoform 3 Rap_GAP

PDB templates used: 3brw_D, 3brw_B

Seq identity: 0.416, 0.315 Model score: 0.265

ELASPIC ΔΔG: -0.160

ELASPIC2 (EL2) score: 2.481

Mutation in database: COSMIC.

Download:  PDBwt   | PDBmut

Citation

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