ELASPIC home << Job #oncokb << Q15382.Y35H
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
For more information see the ELASPIC publication.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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Q15382.Y35H

Detailed results for job #oncokb produced by ELASPIC
Q15382, GTP-binding protein Rheb:
Y35H
1
184
Ras
TSC2, Tuberin:
1
1807
Rap_GAP
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Protein: Q15382 | TSC2 | Cofactors | All
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Q15382.Y35H

Completed successfully

Protein, domain: Q15382 Ras

Interacting with: TSC2 Rap_GAP

PDB templates used: 3brw_D, 3brw_B

Seq identity: 0.416, 0.315 Model score: 0.360

ELASPIC ΔΔG: 0.471

ELASPIC2 (EL2) score: 2.376

Mutation in database: COSMIC.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.