ELASPIC home << Job #oncokb << Q15303.R544W
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
For more information see the ELASPIC publication.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

Q15303.R544W

Detailed results for job #oncokb produced by ELASPIC
Q15303, Receptor tyrosine-protein kinase erbB-4:
R544W
1
1308
Pkinase_Tyr
Furin..
Recep_L..
Recep_L_..
GF_rec..
EGFR isoform 3, Isoform 3 of Epidermal growth factor receptor:
1
705
Recep_L_domain
Recep_L_domain
Furin-like
G..
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Q15303.R544W

Completed successfully

Protein, domain: Q15303 GF_recep_IV

Interacting with: EGFR isoform 3 GF_recep_IV

PDB templates used: 3ltf_A, 3ltf_C

Seq identity: 0.404, 0.320 Model score: 2.247

ELASPIC ΔΔG: 0.765

ELASPIC2 (EL2) score: 0.710

Mutation in database: COSMIC.

Download:  PDBwt   | PDBmut

Citation

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