ELASPIC home << Job #oncokb << Q15303.M887I
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

Q15303.M887I

Detailed results for job #oncokb produced by ELASPIC
Q15303, Receptor tyrosine-protein kinase erbB-4:
M887I
1
1308
Pkinase_Tyr
Furin..
Recep_L..
Recep_L_..
GF_rec..
P85A isoform 4, Isoform 4 of Phosphatidylinositol 3-kinase regulatory subunit alpha:
1
732
SH2+SH2
RhoGAP
SH3_2
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Q15303.M887I

Completed successfully

Protein, domain: Q15303 Pkinase_Tyr

Interacting with: P85A isoform 4 SH2+SH2

PDB templates used: 4gl9_A, 4gl9_E

Seq identity: 0.358, 0.304 Model score: 0.291

ELASPIC ΔΔG: 1.145

ELASPIC2 (EL2) score: -0.150

Mutation run by user.

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Citation

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