ELASPIC home << Job #oncokb << Q13485.D537E
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
For more information see the ELASPIC publication.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

Q13485.D537E

Detailed results for job #oncokb produced by ELASPIC
Q13485, Mothers against decapentaplegic homolog 4:
D537E
1
552
MH1
MH2
SMAD6, Mothers against decapentaplegic homolog 6:
1
496
MH1
MH2
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Model: Wild-type | Mutant | Both
Protein: Q13485 | SMAD6 | Cofactors | All
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Q13485.D537E

Completed successfully

Protein, domain: Q13485 MH2

Interacting with: SMAD6 MH2

PDB templates used: 1dd1_B, 1dd1_A

Seq identity: 0.929, 0.362 Model score: -0.149

ELASPIC ΔΔG: 0.275

ELASPIC2 (EL2) score: 1.367

Mutation in databases: COSMIC, COSMIC.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.