ELASPIC home << Job #oncokb << Q13233.E1286V
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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Q13233.E1286V

Detailed results for job #oncokb produced by ELASPIC
Q13233, Mitogen-activated protein kinase kinase kinase 1:
E1286V
1
1512
Pkinase
ACTN1, Alpha-actinin-1:
1
892
Spectrin
EF-ha..
EFha..
CH
CH
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Model: Wild-type | Mutant | Both
Protein: Q13233 | ACTN1 | Cofactors | All
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Q13233.E1286V

Completed successfully

Protein, domain: Q13233 Pkinase

Interacting with: ACTN1 EF-hand_6

PDB templates used: 2x0g_A, 2x0g_B

Seq identity: 0.267, 0.333 Model score: 0.819

ELASPIC ΔΔG: 2.532

ELASPIC2 (EL2) score: -0.229

Mutation run by user.

Download:  PDBwt   | PDBmut

Citation

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