ELASPIC home << Job #oncokb << Q13233.E1286V
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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Q13233.E1286V

Detailed results for job #oncokb produced by ELASPIC
Q13233, Mitogen-activated protein kinase kinase kinase 1:
E1286V
1
1512
Pkinase
MAP3K7, Mitogen-activated protein kinase kinase kinase 7:
1
606
Pkinase_Tyr
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Model: Wild-type | Mutant | Both
Protein: Q13233 | MAP3K7 | Cofactors | All
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Q13233.E1286V

Completed successfully

Protein, domain: Q13233 Pkinase

Interacting with: MAP3K7 Pkinase_Tyr

PDB templates used: 4idt_A, 4idt_B

Seq identity: 0.319, 0.288 Model score: 1.222

ELASPIC ΔΔG: 1.347

ELASPIC2 (EL2) score: -0.213

Mutation run by user.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.