ELASPIC home << Job #oncokb << Q06187.Y551F
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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Q06187.Y551F

Detailed results for job #oncokb produced by ELASPIC
Q06187, Tyrosine-protein kinase BTK:
Y551F
1
659
PH+BTK
Pkinase_Tyr
SH3_1
SH2
KPCZ isoform 2, Isoform 2 of Protein kinase C zeta type:
1
409
Pkinase+Pkinase_C
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Q06187.Y551F

Completed successfully

Protein, domain: Q06187 Pkinase_Tyr

Interacting with: KPCZ isoform 2 Pkinase+Pkinase_C

PDB templates used: 3p08_A, 3p08_B

Seq identity: 0.951, 0.238 Model score: 0.417

ELASPIC ΔΔG: 0.416

ELASPIC2 (EL2) score: 1.044

Mutation run by user.

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Citation

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