ELASPIC home << Job #oncokb << Q06187.R544S
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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Q06187.R544S

Detailed results for job #oncokb produced by ELASPIC
Q06187, Tyrosine-protein kinase BTK:
R544S
1
659
PH+BTK
Pkinase_Tyr
SH3_1
SH2
ZAP70 isoform 3, Isoform 3 of Tyrosine-protein kinase ZAP-70:
1
493
Pkinase_Tyr
SH2
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Q06187.R544S

Completed successfully

Protein, domain: Q06187 Pkinase_Tyr

Interacting with: ZAP70 isoform 3 Pkinase_Tyr

PDB templates used: 3p08_B, 3p08_A

Seq identity: 0.977, 0.376 Model score: -0.209

ELASPIC ΔΔG: 2.175

ELASPIC2 (EL2) score: 1.750

Mutation run by user.

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Citation

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