ELASPIC home << Job #oncokb << Q06187.R544S
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

Q06187.R544S

Detailed results for job #oncokb produced by ELASPIC
Q06187, Tyrosine-protein kinase BTK:
R544S
1
659
PH+BTK
Pkinase_Tyr
SH3_1
SH2
KPCB isoform 2, Isoform Beta-II of Protein kinase C beta type:
1
673
C1_1
C1_1
C2
Pkinase+Pkinase_C
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Q06187.R544S

Completed successfully

Protein, domain: Q06187 Pkinase_Tyr

Interacting with: KPCB isoform 2 Pkinase+Pkinase_C

PDB templates used: 3iw4_A, 3iw4_B

Seq identity: 0.254, 0.854 Model score: 0.321

ELASPIC ΔΔG:

ELASPIC2 (EL2) score: 1.574

Mutation run by user.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.