ELASPIC home << Job #oncokb << Q06187.C481S
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

Q06187.C481S

Detailed results for job #oncokb produced by ELASPIC
Q06187, Tyrosine-protein kinase BTK:
C481S
1
659
PH+BTK
Pkinase_Tyr
SH3_1
SH2
C-Met, Hepatocyte growth factor receptor:
1
1390
Pkinase_Tyr
TIG
Sema+PSI
TIG
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Protein: Q06187 | C-Met | Cofactors | All
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Q06187.C481S

Completed successfully

Protein, domain: Q06187 Pkinase_Tyr

Interacting with: C-Met Pkinase_Tyr

PDB templates used: 3p08_B, 3p08_A

Seq identity: 0.977, 0.346 Model score: -0.530

ELASPIC ΔΔG: 0.978

ELASPIC2 (EL2) score: -1.027

Mutation in database: UniProt.

Download:  PDBwt   | PDBmut

Citation

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