ELASPIC home << Job #oncokb << Q06124.A72S
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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Q06124.A72S

Detailed results for job #oncokb produced by ELASPIC
Q06124, Tyrosine-protein phosphatase non-receptor type 11:
A72S
1
597
SH2
SH2
Y_phosphatase
HCK isoform 4, Isoform 4 of Tyrosine-protein kinase HCK:
1
525
SH3_1
SH2
Pkinase_Tyr
Select affected interaction:

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Q06124.A72S

Completed successfully

Protein, domain: Q06124 SH2

Interacting with: HCK isoform 4 SH2

PDB templates used: 1r1s_A, 1r1s_E

Seq identity: 0.442, 0.388 Model score: 0.123

ELASPIC ΔΔG: 0.211

ELASPIC2 (EL2) score: -1.263

Mutation in database: UniProt.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.