ELASPIC home << Job #oncokb << P63000.Q61R
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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P63000.Q61R

Detailed results for job #oncokb produced by ELASPIC
P63000, Ras-related C3 botulinum toxin substrate 1:
Q61R
1
192
Ras
KALRN, Kalirin:
1
2985
Spectrin
Rho..
Rho..
..
..
Pkinase
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Model: Wild-type | Mutant | Both
Protein: P63000 | KALRN | Cofactors | All
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P63000.Q61R

Completed successfully

Protein, domain: P63000 Ras

Interacting with: KALRN RhoGEF

PDB templates used: 1kz7_D, 1kz7_C

Seq identity: 0.723, 0.458 Model score: -1.224

ELASPIC ΔΔG: 0.446

ELASPIC2 (EL2) score: 2.320

Mutation in database: COSMIC.

Download:  PDBwt   | PDBmut

Citation

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