ELASPIC home << Job #oncokb << P63000.Q61R
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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P63000.Q61R

Detailed results for job #oncokb produced by ELASPIC
P63000, Ras-related C3 botulinum toxin substrate 1:
Q61R
1
192
Ras
MCF2L isoform 2, Isoform 2 of Guanine nucleotide exchange factor DBS:
1
1096
RhoGEF
Spectrin
Select affected interaction:

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P63000.Q61R

Completed successfully

Protein, domain: P63000 Ras

Interacting with: MCF2L isoform 2 RhoGEF

PDB templates used: 1kz7_D, 1kz7_C

Seq identity: 0.723, 0.938 Model score: -1.320

ELASPIC ΔΔG: 0.235

ELASPIC2 (EL2) score: 2.731

Mutation in database: COSMIC.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.