ELASPIC home << Job #oncokb << P61586.E40W
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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P61586.E40W

Detailed results for job #oncokb produced by ELASPIC
P61586, Transforming protein RhoA:
E40W
1
193
Ras
ARHG3 isoform 2, Isoform 2 of Rho guanine nucleotide exchange factor 3:
1
558
RhoGEF
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P61586.E40W

Completed successfully

Protein, domain: P61586 Ras

Interacting with: ARHG3 isoform 2 RhoGEF

PDB templates used: 2vrw_A, 2vrw_B

Seq identity: 0.598, 0.250 Model score: -0.926

ELASPIC ΔΔG: 0.626

ELASPIC2 (EL2) score: 2.301

Mutation run by user.

Download:  PDBwt   | PDBmut

Citation

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