ELASPIC home << Job #oncokb << P61586.E40Q
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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P61586.E40Q

Detailed results for job #oncokb produced by ELASPIC
P61586, Transforming protein RhoA:
E40Q
1
193
Ras
TRIO, Triple functional domain protein:
1
3097
..
Spectrin
Rh..
Rho..
Pkin..
Pkin..
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Model: Wild-type | Mutant | Both
Protein: P61586 | TRIO | Cofactors | All
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P61586.E40Q

Completed successfully

Protein, domain: P61586 Ras

Interacting with: TRIO RhoGEF

PDB templates used: 2rgn_C, 2rgn_B

Seq identity: 1.000, 0.390 Model score: -1.052

ELASPIC ΔΔG: -0.181

ELASPIC2 (EL2) score: 1.715

Mutation in database: COSMIC.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.