ELASPIC home << Job #oncokb << P61586.E40N
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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P61586.E40N

Detailed results for job #oncokb produced by ELASPIC
P61586, Transforming protein RhoA:
E40N
1
193
Ras
ARHGEF12, Rho guanine nucleotide exchange factor 12:
1
1544
RGS-like
RhoGEF
PDZ
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Protein: P61586 | ARHGEF12 | Cofactors | All
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P61586.E40N

Completed successfully

Protein, domain: P61586 Ras

Interacting with: ARHGEF12 RhoGEF

PDB templates used: 2rgn_C, 2rgn_B

Seq identity: 1.000, 0.265 Model score: -0.650

ELASPIC ΔΔG: 0.272

ELASPIC2 (EL2) score: 2.349

Mutation run by user.

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Citation

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