ELASPIC home << Job #oncokb << P61586.E40N
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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P61586.E40N

Detailed results for job #oncokb produced by ELASPIC
P61586, Transforming protein RhoA:
E40N
1
193
Ras
MCF2L, Guanine nucleotide exchange factor DBS:
1
1137
RhoGEF
Spectrin
SH3_2
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Model: Wild-type | Mutant | Both
Protein: P61586 | MCF2L | Cofactors | All
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P61586.E40N

Completed successfully

Protein, domain: P61586 Ras

Interacting with: MCF2L RhoGEF

PDB templates used: 1kz7_D, 1kz7_C

Seq identity: 0.555, 0.938 Model score: -1.425

ELASPIC ΔΔG: 0.182

ELASPIC2 (EL2) score: 2.342

Mutation run by user.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.