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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
For more information see the ELASPIC publication.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

P60484.R335L

Detailed results for job #oncokb produced by ELASPIC

P60484, Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN:
R335L
1
403
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P60484.R335L

Completed successfully

Protein, domain: P60484 PTEN_C2

Type: Core (stability)

PDB template used: 1d5r_A

Seq identity: 0.854 Model score: 0.679

ELASPIC ΔΔG: 0.674

ELASPIC2 (EL2) score: -0.482

Mutation run by user.

Download:  PDBwt   | PDBmut

Citation


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