ELASPIC home << Job #oncokb << P45985.S251N
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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P45985.S251N

Detailed results for job #oncokb produced by ELASPIC
P45985, Dual specificity mitogen-activated protein kinase kinase 4:
S251N
1
399
Pkinase
LRRK2, Leucine-rich repeat serine/threonine-protein kinase 2:
1
2527
LRR
Miro
Pkinase
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Protein: P45985 | LRRK2 | Cofactors | All
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P45985.S251N

Completed successfully

Protein, domain: P45985 Pkinase

Interacting with: LRRK2 Pkinase

PDB templates used: 3enm_C, 3enm_A

Seq identity: 0.557, 0.288 Model score: 0.061

ELASPIC ΔΔG: 0.203

ELASPIC2 (EL2) score: 2.485

Mutation in databases: UniProt, COSMIC.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.