ELASPIC home << Job #oncokb << P45985.G85R
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
For more information see the ELASPIC publication.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

P45985.G85R

Detailed results for job #oncokb produced by ELASPIC
P45985, Dual specificity mitogen-activated protein kinase kinase 4:
G85R
1
399
Pkinase
EGFR, Epidermal growth factor receptor:
1
1210
Recep_L_d..
Recep_..
Furin..
Pkinase_Tyr
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Protein: P45985 | EGFR | Cofactors | All
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P45985.G85R

Completed successfully

Protein, domain: P45985 Pkinase

Interacting with: EGFR Pkinase_Tyr

PDB templates used: 4i24_A, 4i24_B

Seq identity: 0.265, 0.962 Model score: -0.168

ELASPIC ΔΔG: 3.616

ELASPIC2 (EL2) score: 1.285

Mutation in database: COSMIC.

Download:  PDBwt   | PDBmut

Citation

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