ELASPIC home << Job #oncokb << P42771.D84Y
x
Choose which mutations you want to be shown in the result table below.
Reset to show everything.
x
Status of calculations
: Completed with success
: Mutation not in domain
: Running
: In task queue
: Error
When calculations are done, you can click on each mutation to see their detailed results.
x
Try again
can be rerun by clicking the button:
RERUN
For more information about the error, contact us.
x
ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
For more information see the ELASPIC publication.
x
ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

P42771.D84Y

Detailed results for job #oncokb produced by ELASPIC
P42771, Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3:
D84Y
1
156
Ank
B2R6V2, cDNA, FLJ93132, highly similar to Homo sapiens CDC7 cell division cycle 7 (S. cerevisiae) (CDC7), mRNA:
1
574
Pkinase
Pkinase
Select affected interaction:
Set mode: JAVA | HTML5
Set quality: Best | Normal | Worst
Model: Wild-type | Mutant | Both
Protein: P42771 | B2R6V2 | Cofactors | All
Center camera: Protein | Mutation
Clone in larger window
Cartoon: On | Off | Translucent
Sticks: On | Off | Within Å:
Labels: On | Off | Only sticks

P42771.D84Y

Completed successfully

Protein, domain: P42771 Ank

Interacting with: B2R6V2 Pkinase

PDB templates used: 1bi7_B, 1bi7_A

Seq identity: 0.992, 0.368 Model score: 1.285

ELASPIC ΔΔG: 3.870

ELASPIC2 (EL2) score: 0.535

Mutation in databases: UniProt, COSMIC, COSMIC, COSMIC, COSMIC.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.