ELASPIC home << Job #oncokb << P42771.D84V
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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P42771.D84V

Detailed results for job #oncokb produced by ELASPIC
P42771, Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3:
D84V
1
156
Ank
EPHA3, Ephrin type-A receptor 3:
1
983
EphA2_TM+Pkinase_Tyr
SAM_2
Ephrin_lbd
fn3
fn3
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Model: Wild-type | Mutant | Both
Protein: P42771 | EPHA3 | Cofactors | All
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P42771.D84V

Completed successfully

Protein, domain: P42771 Ank

Interacting with: EPHA3 EphA2_TM+Pkinase_Tyr

PDB templates used: 1bi7_B, 1bi7_A

Seq identity: 0.992, 0.261 Model score: 1.819

ELASPIC ΔΔG: 3.048

ELASPIC2 (EL2) score: -0.510

Mutation in databases: COSMIC, COSMIC, COSMIC, COSMIC.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.