ELASPIC home << Job #oncokb << P42345.E2288K
x
Choose which mutations you want to be shown in the result table below.
Reset to show everything.
x
Status of calculations
: Completed with success
: Mutation not in domain
: Running
: In task queue
: Error
When calculations are done, you can click on each mutation to see their detailed results.
x
Try again
can be rerun by clicking the button:
RERUN
For more information about the error, contact us.
x
ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
For more information see the ELASPIC publication.
x
ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

P42345.E2288K

Detailed results for job #oncokb produced by ELASPIC
P42345, Serine/threonine-protein kinase mTOR:
E2288K
1
2549
..
FAT
PI3_PI4..
LST8 isoform 5, Isoform 4 of Target of rapamycin complex subunit LST8:
1
325
WD40
Select affected interaction:
Set mode: JAVA | HTML5
Set quality: Best | Normal | Worst
Model: Wild-type | Mutant | Both
Center camera: Protein | Mutation
Clone in larger window
Cartoon: On | Off | Translucent
Sticks: On | Off | Within Å:
Labels: On | Off | Only sticks

P42345.E2288K

Completed successfully

Protein, domain: P42345 PI3_PI4_kinase

Interacting with: LST8 isoform 5 WD40

PDB templates used: 4jsn_B, 4jsn_D

Seq identity: 1.000, 0.997 Model score: -0.449

ELASPIC ΔΔG: 1.217

ELASPIC2 (EL2) score: 1.297

Mutation run by user.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.