ELASPIC home << Job #oncokb << P42336.N1044K
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
For more information see the ELASPIC publication.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

P42336.N1044K

Detailed results for job #oncokb produced by ELASPIC
P42336, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform:
N1044K
1
1068
PI3K_p85B+PI3K_rbd
PI3K_C2+PI3Ka
PI3_PI4_kinase
SRC, Proto-oncogene tyrosine-protein kinase Src:
1
536
SH3_1
SH2
Pkinase_Tyr
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Model: Wild-type | Mutant | Both
Protein: P42336 | SRC | Cofactors | All
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P42336.N1044K

Completed successfully

Protein, domain: P42336 PI3_PI4_kinase

Interacting with: SRC SH2

PDB templates used: 2y3a_A, 2y3a_B

Seq identity: 0.570, 0.355 Model score: -0.447

ELASPIC ΔΔG: 0.713

ELASPIC2 (EL2) score: -0.526

Mutation in databases: COSMIC, COSMIC, COSMIC, COSMIC.

Download:  PDBwt   | PDBmut

Citation

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